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The high prevalence of genotype F in the Buenos Aires group and its high intragroup heterogeneity agree with the American origin of this genotype. Hepatitis B virus HBV is an etiologic agent of acute and chronic liver disease distributed throughout the world.
Differences in pathogenesis and the probability of becoming a chronic carrier depend on age. The percentage of individuals who become chronically infected with HBV is related to the age at which the infection is acquired.
Therefore, a large reservoir of infection is maintained predominantly by the transmission of HBV to infants. The serologic and genetic classification of that virus has been established. A genetic classification based on the comparison of complete HBV genomes has defined six genotypes, named A to F 11 , It has also been shown that the pattern of clustering obtained with S-gene sequences agrees with the classification based on complete genomes 2 , 10 , Therefore, accumulated S-gene sequences may be used to assess the worldwide molecular epidemiology of HBV.
In the present study, HBV isolates from children chronically infected were analyzed to determine the molecular epidemiology of HBV in the pediatric population.